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KMID : 0948320030030010041
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Konyang Medical Journal
2003 Volume.3 No. 1 p.41 ~ p.45
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Noise Overstimulation Induces Changes in Growth Hormone Levels in the Rat Cochlea
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Abstract
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Noise overstimulation stresses several cell types in the cochlea, including hair cells, auditory nerve, stria vascularis and fibrocytes. The cellular response to stress can involve pathways that provide protection, repair and recovery of pathways that lead to cell death. A noise that induces temporary threshold shift (TTS) can induce the ’classic’ stress response in the cochlea, involving heat shock proteins such as HSP70, the neurotrophic factor such as glial cell line derived neurotrophic factor (GDNF). A recent gene microarray study found growth hormone (GH) gene expression also changes immediately following TTS noise. In the current study we used Western blot of the whole cochlea of rat to examine changes in GH following noise. whole cochlea were assessed for GH level by Western blot at 0, 2, 4, 8, 12, 24, 36 and 48 hours following the cessation of noise that would cause TTS, GH protein level decreased at 0 and 2 hour following noise, recovered at 4 hour, and had a second, even greater, decrease at 8 and 12 hours, By 24 hour following noise GH levels returned to normal, sometimes with an ’overshoot’. These result surgest that GH is involved in the stress response in th cochlea and responses biphasically to noise.
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KEYWORD
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Stress response, Inner ear, Growth hormone, Deafness,
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